We present an innovative global-to-local modeling approach to analyze impacts of uncertain and complex futures on Vietnams economy via changes in land use patterns. Socio-economic changes are shown to have major implications for the Vietnamese landscape, including natural forest losses with negative consequences for biodiversity and greenhouse gas emissions, and losses of paddy rice and other agricultural lands in the Red River Delta and the Mekong River delta. Climate-related flood risks in these areas further threaten the population, economic assets, and food security. The scenarios reveal the importance of investments in agriculture, land markets, and climate change mitigation and adaptation.